whatever you are using effects the tone of the music you make !

so yes , a noise supressor will , but you need to know why you need one !

i use one occaionally , especially in conjuction with compression and overdrive.

they are very good if you ‘need ‘ to reduce unwanted noise !

noise suppressor will cut off the lower vollume delays – can be useful though

i’ve been using one for years no problems

make sure you keep your delay/reverb outside the noise cancelling loop

most of your pedal noise will go away if you use a decent power supply with isolated outputs eg voodoo lab pedal power

to prevent the pedals “sucking” your tone you need to buffer the guitar signal with a DI – plug your guitar into the DI and output from DI into pedals

unless you use your amps effects loop then it doesn’t matter

(also i wouldn’t use a multi-effect unit live :D)

Only one thing that scores more Duff points than a noise supressor when playing live, and thats a Reverb pedal, anyone use one live?
Saw the Black Crowes in London last month and every time they finnished a song you could hear a loud hum coming from one of the amps, but try to hear it when they start playing.
Searched through Guitar Geek’s top ten artist rigs, and found only 1 noise gate (same thing??) user, EVH, but he used every effect he could find on his setup, and an early wireless system probably didnt help.
Heres the top 5

http://guitargeek.com/rigview/379/
http://guitargeek.com/rigview/284/
http://guitargeek.com/rigview/293/
http://guitargeek.com/rigview/124/
http://guitargeek.com/rigview/258/

Mustard mitt, I’ve always found a noise limiter a total waste of money. Not up to the job for recording and, as Lee says, hardly worth the effort for the live gig. Made my bass sound ghastly. If the OD pedal is giving you grief, I’d be more tempted to find out why and rectify that directly.

I would always suffer a bit of hiss and crackle rather than use a Tone Sucker. Once you start playing nobody can hear the hiss or hum.
Are you playing with this rig in a band?