Tony launched this site only recently, but already it is a focal point for all those lefty guitar players out there! Remember Jimi was one? Well, here's some more southpaws...

Paul McCartney
Tony Iommi (Black Sabbath)
Elliot Easton (Cars)
Ceasar Rosas (Los Lobos)
Dick Dale (The King of Surf Guitar!)
John Flansberg (They Might Be Giants)
Carl Wahlenger (World Party)
Dave Wankling (English Beat, General Public)
Kurt Cobain
Robbie Merril (Bass-Godsmack)
Doug Pinnick (Bass-King's X)

Fictional Lefties:
Ziggy Stardust (...he played it left hand, but made it too far...)
Homer and Lisa Simpson
AJ of the Bazooka Joe Gang

Bluesers:
Elizabeth Cotten
Albert King
Otis Rush
Lefty Dizz
CoCo Montoya
Little Jimmy King (Albert's Grandson)

Pickers:
Billy Ray Cyrus
Righties but Lefties
David Byrne
The Everly Brothers
Steve Morse
Ric Emmit
Chaaro
Mark Knopfler
Paul Simon

LEFTY GUITAR
http://www.leftyguitar.com

see also

When You Are Left Handed, Right Just Feels Wrong
http://guitarnoise.com/articles/20001115.html
by Tony Nuccio