There are lots of techniques that can be done on a guitar to make playing a particular set notes sound different. If fact, there are so many techniques that they can be hard to remember all at once, especially when in the middle of soloing. Below is a list of things to try (which is by no means complete), intended as an exercise to increase awareness of some of the things you can do.

Note: when trying this kind of stuff, it is normal for maybe about half of the stuff you come up with to suck. Hopefully, some of it will sound good. The idea is to throw out the stuff that didn't work and put the good stuff together into a guitar part. The next problem is to write down or record what you liked so you can remember it (and practice it, if needed). .P.S. Enough gain should be used for this exercise to allow artificial harmonics to work , and to provide sufficient sustain for the longer notes.

Also, in the list of guitar techniques below, there are a number of string bends that are a little different from each other. They are listed separately because many guitarists seem to have a natural tendency to use one or two types the most, and may overlook some of the other possibilities. Additionally, the reference in the list below regarding "quick lateral motion" refers to playing notes one-at-a-time on different strings at the same fret (something that many guitarists tend to avoid trying) which is usually accomplished by using a single finger for fretting and just quickly moving it from one string to the next (while damping immediately adjacent strings with the same finger, if needed).

So anyway, the exercise is to make up a little lead guitar part with the following items included... See them here: http://www.guitartricks.com/wanlass/practex.shtml