I’ve got a GT6 and have been using it for almost a year now…and what joy!!! Yes, it is a bit complicated to understand initially, but with all good things in life you have to spend a bit of time with it. I have some amazing sounds coming from this beast and I’m only using this pedal when doing live gigs etc.! There’s almost no sound that you can’t replicate with this baby! With regards to the ME-50, I’ve heard some people complain about a sound delay when switching between banks. There is none of this on the GT6.

Also, go to the following link and see what other people have to say about the two models. They also rate the 2 models on different features. This should give you a good idea about which one to go for.

http://www.harmony-central.com/Effects/Data/Boss/